Flavonoids from the bark of Garcinia lanessanii Pierre

Abstract

Garcinia lanessanii Pierre belongs to the genus Garcinia of the Guttiferae (Clusiaceae) family. In Cambodia, people use this species to cure sore throat and tooth decay. However, chemical and biological study of this species has been not reported in the world until now. To contribute to chemical knowledge of the genus Garcinia in Viet Nam, we chemically investigated the species Garcinia lanessanii Pierre. The bark of this plant collected in the National Forest Lo Go – Xa Mat, Tan Bien ward, Tay Ninh province was dried, ground into powder and extracted in turn with n-hexane, chloroform and ethyl acetate solvents by using a Sohxlet system. Four flavonoids were isolated from the ethyl extract of G. lanessanii Pierre using column and thin layer chromatography on silica gel, RP-18 and Sephadex LH-20 with different solvents. Based on the analysis of 1D and 2D NMR spectra as well as comparison with literature, the structures of these compounds were elucidated as a flavanone, naringenin (1); two biflavonoids, volkensiflavone (2) and GB-2 (3), together with a biflavonoid glycoside, volkensiflavone-7-O-rhamnopyranoside (4). These compounds were isolated from G. lanessanii Pierre for the first time.