Chromenes and coumarins from the roots of Paramignya trimera

Abstract

Paramignya trimera, which belongs to the family Rutaceae, is used for the treatment of liver inflammation and cancer. Previous studies revealed that the roots of the species contained alkaloids, coumarins and chromenes. In this study, we reported the isolation of seven compounds from the roots collected in Phu Yen Province, comprising three chromenes, 2,2-dimethylchrom-3-en-6- carboxaldehyde (1), eulatachromene (2) and ninhvanin (3), together with four coumarins, 7- demethylsuberosin (4), xanthyletin (5), 6,7- dihydroxycoumarin (6) and 6-methoxy-7- hydroxycoumarin (7). Their chemical structures were elucidated using NMR techniques.