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Abstract

Mangifera reba (Mangifera), belonging to the Anacardiaceae family, grows mainly in tropical and subtropical countries such as India, Vietnam, Malaysia and Thailand. Its chemical constituents are triterpenoids, flavonoids, xanthones, benzophenones and polyphenols. Previous studies presented that Mangifera reba contained abundant biological activities such as antibacterial, antioxidant and cytotoxic activity against breast cancer cell line MCF-7. However, research and databases in Vietnam are little available for this species. This paper presented the chemical constituents from the stems of Mangifera reba to provide more information to the database on medical plants in Vietnam. By using silica gel column chromatography and preparative TLC, eluting with organic solvents of different polarity, the ethyl acetate extract from the stems of Mangifera reba, collected from Dong Nai province in 2014, five flavonoids (−)-naringenin (1), (−)-eriodictyol (2), (+)-taxifolin (3), kaempferol (4) and quercetin (5) were isolated. The chemical structures of these compounds were elucidated based on the MS, NMR spectroscopic analysis and comparison with the literature. All 5 isolated compounds with IC50 values of 4.3−84.9 μM showed more potential inhibitory activity than the positive control acarbose (IC50, 214.5 μM).



Author's Affiliation
  • Thanh Truc Duong

    Google Scholar Pubmed

  • Tho Huu Le

    Google Scholar Pubmed

  • Nhat Truong Do

    Google Scholar Pubmed

  • Hai Nguyen

    Google Scholar Pubmed

  • Tu Hoai Tran

    Google Scholar Pubmed

  • Phu Hoang Dang

    Email I'd for correspondance: dhphu@hcmus.edu.vn
    Google Scholar Pubmed

  • Nhan Trung Nguyen

    Google Scholar Pubmed

  • Mai Nguyen Thi-Thanh

    Google Scholar Pubmed

Article Details

Issue: Vol 8 No Online First (2024): Online First
Page No.: In press
Published: Sep 30, 2024
Section: Original Research
DOI:

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Creative Commons License

Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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 How to Cite
Duong, T. T., Le, T., Do, N. T., Nguyen, H., Tran, T., Dang, P., Nguyen, N., & Nguyen Thi-Thanh, M. (2024). Five flavonoids from the stems of Mangifera reba and their -glucosidase inhibitory activity. Science & Technology Development Journal: Natural Sciences, 8(Online First), In press. Retrieved from https://stdjns.scienceandtechnology.com.vn/index.php/stdjns/article/view/1318

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