Evaluate the efficiency of resveratrol for treating Parkinson disease on Drosophila melanogaster model

Abstract

Parkinson's is the second most common neurodegenerative disease in the world (after Alzheimer's), characterized by the degeneration of dopaminergic neurons and mobility impairment, which consequently severely reduces patient life quality. Up to now, Parkinson's Disease cannot be completely cured. Base on the relationship between oxidative stress and the formation, the progression of Parkinson's Disease, antioxidant compounds have been studied as potential candidates in rescue or retard disease progression. Resveratrol is a strong antioxidant, anti-inflammatory, anti-apoptosis compound that exists in many fruits, especially grapes, strawberries..., and has activity depends on the used concentration. In this study, we evaluated the potential of resveratrol for treating Parkinson's Disease at concentrations of 0.064 mg/g, 0.32 mg/g, 0.64 mg/g by utilizing the knockdown dUCH (Drosophila ubiquitin carboxyl-terminal hydrolase) Drosophila melanogaster model. This model can mimic the typical symptoms of Parkinson's Disease and has been proved for the efficiency in screening drugs to treat the disease. Our results showed that the use of resveratrol at a concentration of 0.32 mg/g was effective in preventing the degeneration of dopaminergic neurons and improving mobility in dUCH knockdown flies. These results provided scientific evidence for the development of functional products or drugs to support Parkinson's Disease treatment.