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Abstract

Curcumin is extracted from turmeric exhibiting several biomedical activities. Unfortunately, less aqueous solubility was still a drawback to apply it in medicine. This study introduced a method to produce a thermosensitive nanocomposite hydrogel (nCur-PG) containing curcumin nanoparticles (nCur) which can overcome the poor dissolution of curcumin. Regarding to the method, a thermo-reversible pluronic F127-grafted gelatin (PG) play a role as surfactant to disperse and protect nanocurcumin from aggregation. The synthetic PG was identified by 1H-NMR. The obtained results via Transmission Electron Microscopy (TEM) and Dynamic Light Scattering (DLS) indicated that the size of nCur was various in the range from 1.5 ± 0.5 to 128 ± 9.7 nm belong to amount of the fed curcurmin. The nCur-dispersed PG solution formed nCur-PG when the solution was warmed up to 34-35 oC. Release profile indicated sustainable release of curcumin from hydrogel. Thermosensitive nanocomposite hydrogel based pluronic-grafted gelatin and nanocurcumin performed potential application of the biomaterial in tissue regeneration.



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Article Details

Issue: Vol 2 No 4 (2018)
Page No.: 146-154
Published: Aug 14, 2019
Section: Original Research
DOI: https://doi.org/10.32508/stdjns.v2i4.822

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Creative Commons License

Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 How to Cite
Huynh, T., Tran, H., Doan, V., & Tran, Q. (2019). Thermosensitive nanocomposite hydrogel based pluronic-grafted gelatin and nanocurcumin for enhancing burn healing. Science and Technology Development Journal - Natural Sciences, 2(4), 146-154. https://doi.org/https://doi.org/10.32508/stdjns.v2i4.822

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