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Abstract

Sulfated exopolysaccharides have been well-known to enhance biological activities. Exopolysaccharide (EPS) produced by Ophiocordyceps sinensis fungus is a source of natural compounds. The aim of our study is to improve the EPS biological activities by its sulfated modification using the chlorosulfonic acid (CSA)-pyridine (Pyr) method. The appropriate conditions of the sulfation reaction were explored, including CSA/Pyr ratio (v/v) of 1:3 and 6h. The degree of substitution (DS) of S-EPS11 was the highest (DS = 1.59). The total contents of polysaccharides and SO42- of S-EPS11 were 52.25% and 47.15%, respectively. Besides, the FT-IR spectra analysis indicated the presence of CO-S (peak of 815 cm-1) and S=O (peak of 1129 cm-1) stretching vibrations, while the natural EPS did not appear. Importantly, OH• and ABTS• radical scavenging potential of S-EPS11 significantly increased compared with those of the natural EPS. Together, we successfully generated sulfated EPS extracted from O. sinensis fungus which enhanced antioxidant activities of natural EPS.



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Article Details

Issue: Vol 2 No 4 (2018)
Page No.: 24-31
Published: Aug 13, 2019
Section: Original Research
DOI: https://doi.org/10.32508/stdjns.v2i4.806

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Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 How to Cite
Tran, T., Nguyen, P., Nguyen, L., Le, H., Huynh, T., & Dinh, H. (2019). Preparation of a sulfated exopolysaccharide (S-EPS) from Ophiocordyceps sinensis fungus and its antioxidant effects. Science and Technology Development Journal - Natural Sciences, 2(4), 24-31. https://doi.org/https://doi.org/10.32508/stdjns.v2i4.806

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