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Electrospraying is an effective method to produce polycaprolactone microparticles for drug or protein carrier application. In this study, some factors which influenced the morphology of polycaprolactone (PCL) particles were investigated by Scanning Electron Microscopy (SEM), such as polymer concentration, solvent and distance from tip to the collector. The SEM micrographs indicated that the low concentration (1 %) of PCL solution created in wrinkled and hollow semi-spheres while wrinkled spheres were formed by using higher polymer concentration (4 %). The spherical morphology was obtained when the polymer concentration was high enough (4 %) to create significant chain entanglements. In addition, chloroform and dichloromethane were good solvents to fabricate electrosprayed microspheres. Solvent mixtures such as acetone and chloroform or Dimethylformamide (DMF) and chloroform were unsuitable for electrosprayed particles since they caused unstable and heterogeneous shape. This research demonstrated that the morphology of microparticles was controlled by adjusting parameters of electrospraying to have a homogeneous and stable morphology.

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Issue: Vol 1 No T4 (2017)
Page No.: 130-137
Published: Dec 31, 2017
Section: Original Research

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Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 How to Cite
Viet Linh, N. V., & Dai Phu, H. (2017). Controlling the morphology of polycaprolactone microparticles produced by electrospraying. Science and Technology Development Journal - Natural Sciences, 1(T4), 130-137.

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