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Abstract
Paramignya trimera is a woody shrub and has distribution in tropical areas. This plant has been traditionally used in Vietnam for treatments of diabetes, liver diseases. Coumarins and alkaloids are the main constituents in this plant. Moreover, phytochemical investigations of stems and roots of Paramignya trimera indicated that this plant possessed various bioactivities such as antioxidant, anti-inflammatory, and cytotoxicity. In this study, the aim is to isolate chemical constituents from the leaves of Paramignya trimera (Rutaceae). This work would provide more chemical data of Paramignya trimera in Vietnam. By using silica gel column chromatography, preparative TLC five flavonoids pinostrobin (1), pinocembrin (2), tangeretin (3), nobiletin (4), and sciadopitysin (5), were isolated from the CHCl3 extract of leaves of P. trimera (Rutaceae) collected in Dong Nai Province in January, 2021. Their chemical structures were determined by 1D and 2D NMR spectroscopy and comparison with published data. All compounds were reported in the first time from the leaves of P. trimera.
Issue: Vol 7 No 3 (2023): Vol 7 (3): Under publishing
Page No.: In press
Published: Aug 11, 2023
Section: Original Research
DOI: https://doi.org/10.32508/stdjns.v7i3.1264
Funding data
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Viet Nam National University Ho Chi Minh City
Grant numbers 562-2022-18-02
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