Flavonoids from leaves of Paramignya trimera (Rutaceae)

Abstract

Paramignya trimera is a woody shrub and has distribution in tropical areas. This plant has been traditionally used in Vietnam for treatments of diabetes, liver diseases. Coumarins and alkaloids are the main constituents in this plant. Moreover, phytochemical investigations of stems and roots of Paramignya trimera indicated that this plant possessed various bioactivities such as antioxidant, anti-inflammatory, and cytotoxicity. In this study, the aim is to isolate chemical constituents from the leaves of Paramignya trimera (Rutaceae). This work would provide more chemical data of Paramignya trimera in Vietnam. By using silica gel column chromatography, preparative TLC five flavonoids pinostrobin (1), pinocembrin (2), tangeretin (3), nobiletin (4), and sciadopitysin (5), were isolated from the CHCl₃ extract of leaves of P. trimera (Rutaceae) collected in Dong Nai Province in January, 2021. Their chemical structures were determined by 1D and 2D NMR spectroscopy and comparison with published data. All compounds were reported in the first time from the leaves of P. trimera.