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Paramignya trimera is a woody shrub and has distribution in tropical areas. This plant has been traditionally used in Vietnam for treatments of diabetes, liver diseases. Coumarins and alkaloids are the main constituents in this plant. Moreover, phytochemical investigations of stems and roots of Paramignya trimera indicated that this plant possessed various bioactivities such as antioxidant, anti-inflammatory, and cytotoxicity. In this study, the aim is to isolate chemical constituents from the leaves of Paramignya trimera (Rutaceae). This work would provide more chemical data of Paramignya trimera in Vietnam. By using silica gel column chromatography, preparative TLC five flavonoids pinostrobin (1), pinocembrin (2), tangeretin (3), nobiletin (4), and sciadopitysin (5), were isolated from the CHCl3 extract of leaves of P. trimera (Rutaceae) collected in Dong Nai Province in January, 2021. Their chemical structures were determined by 1D and 2D NMR spectroscopy and comparison with published data. All compounds were reported in the first time from the leaves of P. trimera.

Author's Affiliation
  • Dinh Hieu Nguyen Tran

    Google Scholar Pubmed

  • Tu Hoai Tran

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  • Nhan Trung Nguyen

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  • Phu Hoang Dang

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Article Details

Issue: Vol 7 No 3 (2023): Vol 7 (3): Under publishing
Page No.: In press
Published: Aug 11, 2023
Section: Original Research

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Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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 How to Cite
Nguyen Tran, D. H., Tran, T., Nguyen, N., & Dang, P. (2023). Flavonoids from leaves of Paramignya trimera (Rutaceae). VNUHCM Journal of Natural Sciences, 7(3), In press.

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