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This paper reported the isolation of chemical constituents from the chloroform extract of aerial parts of Helicteres hirsuta Lour (Malvaceae) and isolated compounds were evaluated for their α-glucosidase inhibitory. This work aimed to discover effective α-glucosidase inhibitors for scientific evidence in using medicinal plants for diabetic treatment in Vietnamese traditional medicines as well as developing drugs for diabetic treatment. From the CHCl3-soluble fraction of the aerial parts of Helicteres hirsuta Lour, collected in An Giang province, four compounds, including (+)-pinoresinol (1), (3,4-dihydroxyphenyl)acetic acid ethyl ester (2), 7-O-methylisoscutellarein (3) and ethyl 3-(3,4-dihydroxyphenyl)lactate (4) were isolated. Their chemical structures were elucidated based on the NMR spectroscopic analysis and comparison with data in the literature. All four isolated compounds (1‒4) showed good α-glucosidase inhibitory assay activity with the IC50¬ of 37.9, 69.1, 12.5, 9.4 µM, respectively, better than that of the positive control acarbose (IC50¬ 168.0)

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Issue: Vol 6 No 3 (2022): Vol 6, Issue 3: Under publishing
Page No.: In press
Published: Sep 1, 2022
Section: Original Research

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Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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 How to Cite
Nguyen, T. L., Tran, H. T., Tran, N. M., Pham, H. Q., Dang, P., Duong, T. T., & Nguyen, N. (2022). Chemical constituents of the aerial parts Helicteres hirsuta Lour (Malvaceae). VNUHCM Journal of Natural Sciences, 6(3), In press.

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