Open Access

Downloads

Download data is not yet available.

Abstract

Iridoid glycosides and tetraterpenoids are the main groups of phytochemicals in the fructus gardenia, These compounds exhibited biological activities such as anti-inflammatory, anti-infective, antioxidant activities; stimulate endothelial cell regeneration, or inhibit liver fibrosis, Vietnamese use gardenia fruit for the treatment of nephritis, urinary tract infections, infectious hepatitis,,, However, studies on chemical compositions and biological activity, Especially, the anti-inflammatory activity of gardenia fruit collected in Dak Lak has not been studied much, In this study, we evaluated the anti-inflammatory activity of the extracts through in vitro model by determining the inhibition of NO and TNF-α and isolated the purified compounds from the bioactive fraction, The results of the anti-inflammatory activity assay on Raw264,7 cells indicated that ethanol 50%, ethanol 70%, and water extracts inhibited NO and TNF-α production, Based on chromatographic techniques using silica gel and macroporous resin D101 as adsorbents, two iridoid compounds as geniposide (1) and genipin-1-O-β-D-gentiobioside (2) were isolated and determined, These two compounds showed a strong inhibitory effect on TNF-α secretion.



Author's Affiliation
Article Details

Issue: Vol 6 No 1 (2022): Vol 6, Issue 1: Under publishing
Page No.: In press
Published: Jan 10, 2022
Section: Original Research
DOI: https://doi.org/10.32508/stdjns.v6i1.1137

 Copyright Info

Creative Commons License

Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 How to Cite
Pham Thi Nhat, T., Hoang, N. A., Phan, V. T., Tong, T. D., Tran Nguyen, M. A., Pham, T., & Le, D. (2022). Chemical constituents and anti-inflammatory activity of the fructus gardeniae (Gardenia Jasminoides Ellis). Science and Technology Development Journal - Natural Sciences, 6(1), In press. https://doi.org/https://doi.org/10.32508/stdjns.v6i1.1137

 Cited by



Article level Metrics by Paperbuzz/Impactstory
Article level Metrics by Altmetrics

 Article Statistics
HTML = 1 times
Online first   = 0 times
Total   = 0 times