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Abstract

Type 2 diabetes mellitus is one of the most common metabolic disorders and causes dangerous complications. The inhibition of α-glucosidase by drugs of natural origin is one of the therapeutic methods that has been used widely for stabilizing postprandial hyperglycemia. Especially, the potential effects of flavonoids in diabetes mellitus have been studied. In this study, the composition investigation of the methanol extract of the leaves of Muntingia calabura L. led to four flavone compounds, including izalpinin (1), 5-hydroxyl-3,7-dimethoxyflavone (2), techtochrysin (3), and methylgnaphaliin (4). The chemical structures of these compounds were determined based on analysis of NMR spectral data and reference comparisons. Four compounds exhibited the α-glucosidase inhibitory effect in a concentration-dependent manner. Compounds izalpinin (1) and 5-hydroxyl-3,7-dimethoxyflavone (2) have the α-glucosidase inhibitory activity with IC50 values of 61.4 and 156.1 µM, respectively, that is more potent than acarbose (IC50 = 214.5 µM). The relationship of the flavone structural and α-glucosidase inhibitory activity showed that a hydroxyl or methoxyl substituent at the olefinic carbon C-3 is likely to increase the activity. In contrast, the presence of methoxyl at the aromatic carbon C-8 strongly reduces the activity. This study has contributed to the natural ingredient and bioactive dataset of Vietnamese medicinal plants for diabetic treatment.



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Issue: Vol 6 No 1 (2022): Vol 6, Issue 1: Under publishing
Page No.: In press
Published: Jan 10, 2022
Section: Original Research
DOI: https://doi.org/10.32508/stdjns.v6i1.1118

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Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 How to Cite
Le, H. T., Tran, T. T. T., Do, T. N. V., Nguyen, H. X., Le, P. T., Nguyen, T. A., & Nguyen, M. T. T. (2022). α-glucosidase inhibitory effect of flavones from the leaves of Muntingia calabura L. Science and Technology Development Journal - Natural Sciences, 6(1), In press. https://doi.org/https://doi.org/10.32508/stdjns.v6i1.1118

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