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Aglaia is the largest genus of the Meliaceae family with about 120 species, which grow mainly in the tropical and subtropical regions. In Vietnam, the genus contains about 30 species. Many are used in folk medicine for the treatment of different diseases. Rocaglamides, bisamides, lignans, triterpenoids and steroids are the main classes of compounds found in the genus. Some of them exhibit diverse biological activities. This research work reports the isolation of four compounds from A. odorata and A. hoaensis. Extraction was carried out using Soxhlet extractors with organic solvents followed by concentration of the solvents to yield crude extracts. Isolation was performed using column chromatography on silica gel and gel permeation on Sephadex LH-20. Chemical structures were determined using 1D NMR (1H, 13C NMR, DEPT), 2D NMR (HSQC, HMBC, COSY, NOESY), IR and HRESIMS spectroscopic methods, and comparison of the spectral data with those in literature. Two triterpenoids, aglaiadoratol and 3b -friedelinol, were isolated from the whole tree of A. odorata. Two other compounds, (+)-syringaresinol lignan and threo-9,10-O-isopropylidene- 13-hydroxy-(11E)-octadecenoic acid, a derivative of fatty acid, were obtained from the bark of A. hoaensis. Among the four isolated compounds, this is the first time that aglaiadoratol has been reported in the world. In addition, (+)-syringares inol ligan and threo-9,10-O-isopropylidene-13- hydroxy-(11E)-octadecenoic acid are reported here for the first time in A. hoaensis.

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Issue: Vol 5 No 3 (2021): Under publishing
Page No.: 1245-1255
Published: May 9, 2021
Section: Original Research

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Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 How to Cite
Nguyen, L. H., Lê, H., Nguyen, T., Nguyen, L., Nguyen, L. T., Bui, T., & Tran, P. (2021). Chemical constituents of Aglaia odorata and Aglaia hoaensis. Science and Technology Development Journal - Natural Sciences, 5(3), 1245-1255.

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