TY - JOUR AU - Tu Tran AU - Phu Dang AU - Tho Le AU - Truong Do Van AU - Hai Nguyen AU - Thanh Mai Nguyen AU - Nhan Nguyen PY - 2022/12/31 Y2 - 2024/03/29 TI - Olean-type triterpenoids from the stems of Salacia chinensis L. (Celastraceae) and theira-glucosidase inhibitory activities JF - Science & Technology Development Journal: Natural Sciences JA - STDJNS VL - 6 IS - 4 SE - Original Research DO - https://doi.org/10.32508/stdjns.v6i4.1207 UR - http://stdjns.scienceandtechnology.com.vn/index.php/stdjns/article/view/1207 AB - In this paper, chemical constituents from the stems of Salacia chinensis L. (Celastraceae) and evaluating their a-glucosidase inhibitory activity were reported. Our study provides more information to the Vietnamese medical plants database. In addition, our study contributes to the search for effective a-glucosidase inhibitors. Four olean-type triterpenoids were isolated from the CHCl3- soluble fraction of the stems of Salacia chinensis L. (Celastraceae) collected in Dong Nai Province. These compounds were identified as 3-epikatonic acid (1), maytenfolic acid (2), regelide (3), and 12,13-dihydrooleanolic acid (4). Their chemical structures were elucidated based on the NMR spectroscopic analysis and comparison with the literature. 3-Epikatonic acid (1) and 12,13- dihydrooleanolic acid (4) showed strong a-glucosidase inhibitory activity, which are better than that of positive control acarbose, with the IC50 values of 76,0; 116,4; and 215,4 mM; respectively. ER -