TY - JOUR AU - Hung Tran AU - Ngan Luong AU - Le Bui AU - Hieu Tran PY - 2023/01/15 Y2 - 2024/03/28 TI - Anti-Helicobacter pylori activities of essential oils extracted from rhizomes of four species of Zingiberaceae family JF - Science & Technology Development Journal: Natural Sciences JA - STDJNS VL - 6 IS - 4 SE - Original Research DO - https://doi.org/10.32508/stdjns.v6i4.1160 UR - http://stdjns.scienceandtechnology.com.vn/index.php/stdjns/article/view/1160 AB - Essential oils (EOs) with a wide spectrum of antibacterial activities have been suggested as potent alternative sources for controlling multidrug-resistant bacteria. This paper presented the evaluation of the anti-H. pylori activity of EOs from rhizomes of Zingiber officinale, Curcuma zedoaria, Curcuma longa and Alpinia officinarum. The Eos, obtained by steam distillation method, were evaluated by their minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), and 50% inhibitory concentration (IC50) of Helicobacter pylori-urease activitiy. The results indicated that the Z. officinale EO exhibited a strong antimicrobial activity towards H. pylori with MIC and MBC values of 0.1 and 1.25 mg/mL, respectively. The Z. officinale EO also showed a strong inhibitory effect against H. pylori-urease in comparison with the three tested EOs, with an IC50 value of 0.2 mg/mL and a complete inhibition at 4 mg/mL. The Z. officinale EO analyzed by GC-MS (gas chromatography-mass spectrometry) was rich in sesquiterpenes (51.9%) and possessed α-zingiberene (21.1%), camphene (12.2%), β-sesquiphellandrene (8.2%), β-bisabolene (7.2%), α-citral (6.8%), eucalyptol (6.3%) and β-citral (5.0%) as major components. Further studies need to be carried out in order to use the Z. officinale EO for the prevention and eradication of H. pylori infection. ER -